Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation

• Status: Completed
• Trial end date: 2019-01-18
• Target enrollment: 0
• Participant gender: All

Summary

The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul St. Mary's Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• elective video-assisted thoracoscopic surgery (VATS) lobectomy

• 20 < age < 75

• American Society of Anesthesiologists (ASA) classification I~II

Exclusion Criteria:

• preoperative inflammation (CRP>10ng/#, WBC>10,000/mm3, body temperature >38#)

• steroid administration within 1 month

• hematologic / autoimmune disease

• congestive heart failure (NYHA class III~IV) or significant arrhythmia

• severe obstructive / restrictive pulmonary disease

• previous history of thoracic surgery