Effect of Diabetes Mellitus on Cholesterol Metabolism
Status:
Completed
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
HMG CoA reductase inhibitors (statins) are commonly used to treat high cholesterol (HC) in
both type 1 and type 2 diabetes mellitus (DM). Several studies have shown benefits of statin
among patients of type 2 DM, however, no such data is available for patients with type 1 DM.
It is known from studies on cholesterol metabolism using surrogate markers that patients with
type 1 DM have higher cholesterol absorption compared to normals and those with type 2 DM
have higher cholesterol synthesis. Since statins inhibit synthesis, patients with type 1 DM
may not have a good response and may respond better to cholesterol absorption inhibitors. The
purpose of this study is to determine the cholesterol lowering effects of cholesterol
absorption inhibitors and cholesterol synthesis inhibitors in subjects with type 1 and type 2
diabetes mellitus.