Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression

• Status: Not yet recruiting
• Trial end date: 2022-02-01
• Target enrollment: 0
• Participant gender: All

Summary

To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on:

• Intensity of post-endodontic pain in patients with symptomatic irreversible pulpitis.

• Pulpal IL-8 expression.

• Incidence of post-endodontic pain in patients with symptomatic irreversible pulpitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Diclofenac; Prednisolone

Criteria

Inclusion Criteria:

• Age between 18-50 years.

• Males and females.

• American Society of Anesthesiologists class 1 or 2.

• Mandibular premolar teeth with:

• Endodontic pulpal diagnosis of symptomatic irreversible pulpitis

• Normal/slight widening in the periodontal membrane space (PMS).

• Patients who had not taken any anti-inflammatory drugs the day of the root canal procedure unless they belong to one of the intervention groups.

• Patients who accept to participate in the trial, understand the VAS, and can sign the informed consent

Exclusion Criteria:

• Cases with acute peri-apical conditions (acute apical periodontitis/ acute apical abscess), pulpal necrosis, previously initiated therapy, or previously treated.

• Teeth other than single-rooted teeth.

• Radiographic evidence of external or internal root resorption vertical root fracture, perforation, or calcification.

• Immature teeth.

• Unrestorable teeth or teeth with severe periodontal disease.

• Patients with a known allergy, sensitivity, or history of other adverse reactions to the medications administered.

• Patients with a history of active peptic ulcer within the preceding 12 months, bleeding problems, anticoagulant use within the last month, or kidney disease.

• Patients who took analgesics/ anti-inflammatory drugs (steroidal or non-steroidal) the day of endodontic treatment.

• Pregnant or nursing females.

• Patients who are unable to provide informed consent