Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
Objectives: This proposal addresses the overall hypothesis that ambient fine particulate
matter exerts cardiovascular health effects via alteration of endothelial homeostasis,
through a mechanism mediated by oxidative stress. This project will use a controlled human
inhalation exposure to diesel exhaust particulate (DEP) as a model to address the following
objectives: 1) Determine whether exposure to inhaled DEP is associated with endothelial
dysfunction in a concentration-related manner; 2) Determine whether exposure to inhaled DEP
is associated with evidence of systemic oxidative stress; and 3) Determine whether
antioxidant supplementation blunts the DEP effect on endothelial function.