Effect of Different Anesthetics on the Change of Alarmins in Lung Cancer Patients Receiving Pulmonary Lobectomy

• Status: Unknown status
• Trial end date: 2019-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aim to observe and compare the change of alarmins such as high mobility group nucleosome-binding protein-1 (HMGN1), high mobility group proteins b1 (HMGb1), Interleukin (IL)-33 and their soluble receptors including soluble toll like receptor 4 (sTLR4) and soluble ST2 (sST2) during pulmonary lobectomy for cancer patients receiving volatile anesthesia or intravenous anesthesia under one-lung ventilation (OLV). By which, this study will preliminarily evaluate the correlation of alarmins and prognosis as well as the effect of inhalational and intravenous anesthesia on the prognosis of surgical patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tianjin Medical University Cancer Institute and Hospital
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• American society of Anesthesiology (ASA) status I-II

• pathological diagnosis of lung cancer before surgery

• receive pulmonary lobectomy

• with normal lung function

• without heart failure (NYHA>2), obstructive or restrictive lung disease

• no history of other malignancy tumor

• body mass index (Body mass, index, BMI) < 35kg/m2

• no severe coagulopathy

• no severe systemic or pulmonary infection

• did not participate in other clinical trials

Exclusion Criteria:

• persistent smoking history

• immunosuppressive drug use 6 weeks before operation

• receive total pneumonectomy

• failure to complete treatment or follow-up

• severe adverse drug reactions

• severe postoperative complications