Effect of Different Intravenous Fluids on Post-operative Chronic Subdural Hematoma Size and Recurrence

• Status: Recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to reduce the recurrence rate of chronic subdural hematomas (CSDH) by manipulating the post-operative intravenous fluid use. The hypothesis relies on the relationship between osmolality and volume changes related to osmolality. We will be administering dextrose 5% in 1/4 normal saline (D5 1/4NS) post-operatively to induce brain expansion which can take up the residual CSDH space, to help reduce recurrence rate.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Carilion Clinic

Criteria

Inclusion Criteria:

• Diagnosis of chronic subdural hematoma (based on imaging)

• Need for surgical intervention (assessed by attending neurosurgeon based on full neurological assessment)

• The procedure of choice is burr hole drainage

• Cessation of anti-coagulant therapy with accompanying normal lab values in appropriate time frames respective to the drug

• Tolerance of supine position

Exclusion Criteria:

• <60 years old

• Presence of acute hemorrhage, stroke, or parenchymal damage

• Neurological deficits not accountable to mass effect

• Hyponatremia or inherent electrolyte imbalances

• Pregnancy or non-consentable patients

• Previous neurological surgery up to 1 year before being considered for the study

• Rapid re-expansion of brain observed intraoperatively by attending neurosurgeon

• Congestive heart failure or other medical conditions precluding normal postoperative administration of IV fluids

• Blood glucose levels > 135 mg/dL