Effect of Different Mouthrinses in Plaque Formation

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Although several studies have assessed the efficacy of chlorhexidine in treating gingivitis and reducing biofilm formation, the side effects of a long-term use are unpleasant for patients. Melaleuca alternifolia oil has been considered as an alternative because of its anti-inflammatory properties. However, little is know about the efficacy of its nanoparticles. The purpose of this study is to compare the effect of 0.12% chlorhexidine (Periogard ®) and a nanoparticle solution of 0.3% M. alternifolia oil in reducing biofilm formation in plaque-free and plaque-covered teeth surfaces.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universidade Federal de Santa Maria
• Collaborator: Centro Universitário Franciscano
• Treatments: Chlorhexidine; Chlorhexidine gluconate; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Individuals must be systemically healthy;

• Must have at least six teeth per quadrant;

• Must not be undergoing medical treatment;

Exclusion Criteria:

• Allergies or hypersensitivity to the components (Chlorhexidine Gluconate or M. alternifolia oil nanoparticles);

• Antibiotic therapy within 3 months prior to baseline examination;

• History of periodontal disease;

• Marginal bleeding index higher than 15%;

• Oral mucosal lesions;

• Pregnancy or breastfeeding;

• Presence of active infectious foci (endodontic abscesses);

• Presence of plaque retentive factors (caries, aesthetic or ill-fitting restorations, orthodontic appliances, fixed or removable prosthesis);

• Smokers;

• Systemic conditions (diabetes, immunosuppression);

• Use of any mouthwash within 21 days prior to baseline examination;