Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the study will be to evaluate the effect of different therapeutic immunosuppressive strategies currently employed in common clinical practice on regulatory T lymphocytes and to verify the hypothesis that the association of thymoglobulins - mTOR inhibitors - small doses of Tacrolimus not only represents a safe anti-rejection therapy but it can also lead to mid-term formation of a high amount of regulatory T cells and, consequently, a high grade of tolerance.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: IRCCS Policlinico S. Matteo
• Treatments: Everolimus; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Sirolimus; Tacrolimus

Criteria

Inclusion Criteria:

• Male and female aged from 18 to 75 years

• Transplanted patients from cadaveric donors

• Patients who has given written informed consensus

Exclusion Criteria:

• Legally unable patients

• Patients who have been participated to others studies in the last 3 months

• Addicted to alcohol or smoking