Effect of Diuretics on Fluid Status Control and Residual Renal Function in Peritoneal Dialysis Patients

• Status: Withdrawn
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

A prospective, randomized, open-label, stratified, controlled clinical trial to evaluate whether long term furosemide therapy (1 year) would preserve urine volume and/or residual renal function (RRF) and improve fluid state in continuous ambulatory peritoneal dialysis (CAPD) patients.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sun Yat-sen University
• Treatments: Diuretics; Furosemide

Criteria

Inclusion Criteria:

• Willingness to sign an informed consent

• Age:20~70 years, regardless of gender

• All patients received CAPD more than 1 months;

• Urine volume of 500ml/d or more;

• No history of taking furosemide for at least 2 weeks .

Exclusion Criteria:

• Inability or unwillingness to sign the informed consent

• Inability or unwillingness to meet the scheme demands raised by the investigators

• Current acute infection such as peritonitis ;

• Severe diarrhea or vomiting within the preceding 1 month

• Acute Cardiac failure

• Myocardial infarction within the preceding 6 months;

• Hypertensive encephalopathy or cerebrovascular accident;

• Accident within the preceding 6 months;

• Any condition, such as alcohol or drug abuse, chronic liver disease, malignant disease, or psychiatric disorder;

• Allergy or intolerance to furosemide .

• Current or recent (within 2 weeks) exposure to any other investigational drugs