Effect of Double Antibiotic Paste Versus Calcium Hydroxide on RANKL/OPG Levels

• Status: Not yet recruiting
• Trial end date: 2022-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study is to evaluate the effect of double antibiotic paste when compared to Ca (OH)2, in terms of RANKL and OPG levels in chronic periapical lesions and correlate the results with periapical bone healing findings after a follow up period of one year.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Anti-Bacterial Agents; Calcium

Criteria

Inclusion Criteria:

• Patients who are free from any physical or mental handicapping conditions and with no underlying systemic diseases.

• Age between 20-45years old.

• Males & Females.

• Single canaled teeth:

• Diagnosed clinically with asymptomatic apical periodontitis.

• Absence of spontaneous pain

• Size of periapical radiolucency: 2-4 mm (i.e. score 3 according to CBCT periapical index proposed by Estrela)30, including only the tested tooth.

• Patients who didn't use any NSAIDs or antibiotics for 1 month before treatment.

• Patients' acceptance to participate in the trial.

Exclusion Criteria:

• - Medically compromised patients.

• Pregnant women.

• Patients reporting bruxism or clenching.

• Patients allergic to ciprofloxacin or metronidazole.

• Teeth associated with acute periapical abscess and/or swelling.

• Greater than grade I mobility or pocket depth greater than 5mm.

• Size of periapical radiolucency is less than 2 mm or greater than 4 mm.

• Non restorable teeth.

• Immature teeth.

• Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.