Effect of Epidural Analgesia on Burst Suppression

• Status: Recruiting
• Trial end date: 2023-04-01
• Target enrollment: 0
• Participant gender: All

Summary

It has been shown in previous studies that burst suppression has an effect on the development of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD). With the development of technology, EEG-based anesthesia management is getting more and more attention. In particular, methods that reduce anesthetic drug consumption are expected to prevent POD and POCD by reducing burst suppression. There are studies that show that epidural analgesia applications reduce general anesthesia drug consumption in patients receiving general anesthesia. In this study, investigators want to investigate the effect of epidural analgesia combined with general anesthesia on burst suppression. POD and POCD development in these patients will be examined as secondary objectives.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bezmialem Vakif University
• Treatments: Bupivacaine; Fentanyl

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) Physical Status 1-3

• Hip or knee arthroplasty surgery

Exclusion Criteria:

• severe renal failure (need for renal replacement therapy)

• severe liver failure (child-pudg grade c)

• body mass index >40

• long-term use of some drugs (sedatives, tricyclic antidepressants, narcotic painkillers)

• having a disease related to the nervous system

• having a psychiatric disease

• having a history of substance abuse

• having consumed 2 or more glasses of alcohol per day in the last 1 year

• contraindications for neuraxial block

• allergy to drugs to be used

• emergency surgeries

• patient's refusal to accept the procedure

• hearing and visual impairment

• anesthesia awareness history

• preoperative delirium