Effect of Eplerenone on Postprandial Inflammatory Response in Healthy Adults
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effect of mineralocorticoid receptor (MR)
blockade in healthy participants in a systemic proinflammatory state after a meal high in fat
and glucose, which is associated with the pathogenesis of atherosclerosis.
Participants will include normal-weight, healthy males (Body Mass Index (BMI) ≤ 25 kg/m^2)
between the ages of 18-45, without hypertension and clinical evidence of metabolic,
cardiovascular or any other kind of diseases. After a 12-hour (h) fast, participants will be
assigned to a combination of oral fat-loading test (OFLT) and oral glucose tolerance test
(OGTT) (day 1), followed by a two-week treatment with 50 mg eplerenone. After two weeks,
participants will receive the second OFLT/OGTT treatment (day 15). Starting 5 days prior to
the first intervention (day1), the participant's usual diet (ad lib) will be supplemented
with 2 bullion broths each day. Standardization of sodium intake is necessary as variations
in dietary sodium intake may affect outcome measures. We will evaluate the following
parameters at day 1 and day 15 of the study. Prior to OFLT/OGTT, and 2h, 4h thereafter, we
will measure a parameter of vascular and systemic inflammation: interleukin-6 (IL-6).