Effect of Erythropoietin on the Incidence of Acute Kidney Injury Following Complex Valvular Heart Surgery
Status:
Completed
Trial end date:
2012-10-01
Target enrollment:
Participant gender:
Summary
Acute kidney injury (AKI) frequently occurs after cardiac surgery using cardiopulmonary
bypass (CPB). Recombinant human erythropoietin (rHuEPO) is known to provide organ protection
against ischemia-reperfusion injury through its anti-inflammatory properties. The aim of the
present study was to investigate the effect of a single preoperative bolus of EPO on the
incidence of AKI following complex valvular heart surgery in a randomized, controlled and
double-blind trial.