Effect of Estrogen Therapy on Objective Sleep Quality in Postmenopausal Women

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

1. Sex hormone including estrogen have synergistic effect to serotonin activity and decrease activity of monoamine oxidase activity so the norepinephrine is not be metabolized, these substance are important to regulate hemostasis and circadian process of sleep

2. Estrogen also regulate gamma-aminobutyric acid (GABA) secretion

• GABA substance is in order to initiate sleep and continue sleep

3. According to epidemiologic data, problem of sleep was increasing in postmenopause group compare to premenopause group (aged-match)

4. This research perform to find out the actual effect of estrogen in improving sleep quality.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Chulalongkorn University
• Treatments: Estrogens

Criteria

Inclusion Criteria:

• Postmenopausal women 40-60 years old

• Mild to moderate vasomotor symptom

• Insomnia

• fluent read and write in Thai language

• Inform consent

Exclusion Criteria:

• Acute liver and gall bladder disease

• undiagnosed abnormal bleeding per vagina

• History of BIRADs 3 from mammogram

• History or current venous thrombosis, embolism

• diagnosis of sleep disorder

• use of hypnotic drug or antihistamine in the past month

• Diagnosis of psychiatric disorder such as depressive disorder, schizophrenia, anxiety disorder

• No past history of malignancy

• No history of chronic renal disease, alzheimer's disease, uncontrolled hypertension, uncontrolled diabetes mellitus

• history of estrogen use in past 6 months

• drug abuse, Alcohol