Effect of Exercise in OI

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The main limitation patients with orthostatic intolerance (OI, or postural tachycardia syndrome, POTS) have to exercise is related to their increase in heart rate when standing. Main pharmacological treatment today is aimed at reducing heart rate with the use of betablockers (propanolol), this theoretically could also improve their exercise capacity; if their heart rate do not increase as much with the medication, they could exercise more. In addition, it has been suggested that in healthy volunteers subjected to head down tilt for 2 weeks (situation that produces a "simulated" transient POTS-like state) a single bout of intense exercise can improve orthostatic tolerance the day after exercising. The mechanisms involved in such response are not that clear but could be an increase in plasma volume already diminished in POTS patients. It seems likely that the same could be true for POTS patients.

The purpose of the present study are to pharmacologically improve the amount of exercise POTS patients can perform by reducing their baseline heart rate (specific aim 1) and to evaluate next day heart responses to an acute bout of intense exercise.

Therefore, the specific aims of this study are:

1. To test the hypothesis that lowering heart rate response with propanolol will result in an increase in exercise capacity.

2. To test the hypothesis that a single bout of exercise will result in an improvement in orthostatic tolerance the day after exercising.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University; Vanderbilt University Medical Center
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• Meet diagnostic criteria of POTS (Raj, et al., 2005)

• Age between 18-65 years

• Male and female are eligible (although the majority of patients POTS are female).

• Able and willing to provide informed consent

Exclusion Criteria:

• Presence of medical conditions that can explain postural tachycardia (e.g., dehydration, medications)

• Pregnancy

• Other factors which in the investigator's opinion would prevent the subject from completing the protocol.

• Patients who are bedridden or chair-ridden.