Effect of Exercise or Metformin on Nocturnal Blood Pressure and Other Risk Factors for CVD Among Obese Adolescents

• Status: Unknown status
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karolinska Institutet
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Age 13-19 years old at inclusion date

• Obesity according to gender and age specific BMI (Cole 2000)

• Reduced nocturnal systolic blood pressure fall (< 10%)

• Signed informed consent by patient and parents

Exclusion Criteria:

• Cardiovascular disease

• Insulin dependent diabetes mellitus

• Patient on medications that are contraindicated during Metformin treatment

• Pregnancy

• Mental or physical conditions limiting the ability to participate