Effect of Exogenous Lactate on Neurocognitive in Brain Trauma

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Mild traumatic brain injury (TBI) is the most common type of brain injury. Post-mild TBI disability could stem from cognitive, physical, psychological and social dysfunction which resulted in significant disability and unemployment. Long-term behavioral impairments which affected the individual's occupation, lifestyle, and family frequently occurred in individuals with mild to moderate brain injuries who physically fully recovered. In-vitro and in-vivo studies showed a better recovery of cognitive function after administration of exogenous lactate in traumatic brain injury. Therefore, this study is aimed to evaluate the effect of exogenous lactate infusion contained in hyperosmolar sodium lactate solution on cognitive function assessed by Mini Mental State Examination(MMSE)scale.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitas Padjadjaran

Criteria

Inclusion Criteria:

• Mild traumatic brain injury

• Glasgow Coma Scale (GCS) of 14-15

• Requires emergency neurosurgery procedures

• Physical status ASA I-II

• Onset of trauma < 9 hours

Exclusion Criteria:

• Multiple injury

• Pregnancy/lactation

• History of alcohol or barbiturate consumption prior to the injury