Effect of Fertility-sparing Therapy of Early Endometrial Cancer

• Status: Unknown status
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to investigate the effect of Fertility-sparing Therapy of Early Endometrial Cancer.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University People's Hospital
• Collaborators: First Affiliated Hospital, Sun Yat-Sen University; Maternal and Child Health Hospital of Hubei Province; Peking University First Hospital; Peking University Third Hospital; Qilu Hospital of Shandong University; Tianjin Medical University General Hospital
• Treatments: Metformin

Criteria

Inclusion Criteria:

• ages of no more than 40

• with a strong desire of fertility preservation

• International Federation of Gynecology and Obstetrics (FIGO) 2009 stage Ⅰa grade 1~2 with lesion confined in endometrium

• pathology expression of progestin receptors (PRs) and estrogen receptors

Exclusion Criteria:

• not eligible for pregnancy or delivery

• evidence of suspected extrauterine or distant metastasis

• complicated with any other malignancy

• severe medical complications

• contraindication of oral progestin

• uncontrolled epilepsy, central nervous system disease or mental disorder history in patients which Influence clinical research compliance judging by the researcher.