Effect of Flumazenil on Recovery From General Anesthesia With Isoflurane
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
Background and objectives: The inhalational anesthetic isoflurane is widely used in general
anesthetics. Its mechanism of action involves interaction with the receptor of gamma-amino
butyric acid (GABA), which is also the binding site for benzodiazepines. Flumazenil,
benzodiazepine antagonist, reverses the effects of these drugs in GABA receptors and could
therefore also reverse the effect of isoflurane. In anesthesia practice, extubation and early
anesthetic recovery reduce morbidity and incidence of complications. The objective of this
trial is to determine whether the use of flumazenil may contribute to faster recovery from
anesthesia. Methods: 40 patients scheduled to undergo general anesthesia with isoflurane were
enrolled in this prospective, double-blind, randomized trial. Patients were randomized to
receive, at the end of anesthesia, flumazenil or placebo as allocated into two groups. The
anesthetic technique was standardized. The groups were compared concerning values of Cerebral
State Index (CSI), heart rate, blood pressure and oxygen saturation from the application of
flumazenil or placebo until 30 minutes after injection. Data regarding time to extubation,
time to reach ten points in the Aldrete-Kroulic score (AK = 10) and Vigilance score (VS = 10)
was also collected. ANOVA test was applied to analyze the results, considering p <0.05.