Effect of Flutamide on Biomarkers in Blood and Tissue Samples From Patients at High Risk of Ovarian Cancer
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
Studying samples of blood and tissue in the laboratory from patients with a high risk of
developing ovarian cancer may help doctors identify and learn more about biomarkers related
to cancer. We hypothesized that (i) preclinical biologic evidence exists for the role of
androgens in ovarian cancer development and (ii) flutamide treatment of women at high risk
for ovarian cancer may identify meaningful tissue biomarkers of androgen action and of
ovarian cancer initiation. This phase II trial studied the effect of flutamide on biomarkers
in blood and tissue samples from patients at high risk of ovarian cancer.