Effect of Fluticasone Furoate on Methacholine Challenge

• Status: Completed
• Trial end date: 2019-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The study will determine the effect of inhaled fluticasone furoate on airway responsiveness to methacholine in mild asthmatics.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Treatments: Fluticasone; Methacholine Chloride; Xhance

Criteria

Inclusion Criteria:

• forced expiratory volume in one second (FEV1) greater than or equal to 65% predicted

• methacholine PD20 less than or equal to 400mcg

• no allergen exposure (if atopic) or respiratory infection for at least 4 weeks prior to study start

Exclusion Criteria:

• regular use of inhaled corticosteroid within 4 weeks of study start

• poorly controlled asthma

• current smoker or ex smoker with greater than 10 pack year history

• pregnancy or breast-feeding

• health concern/condition that would preclude participation for safety reasons