Effect of Folic Acid on Endothelial and Baroreceptor Function in Patients With Heart Failure

• Status: Terminated
• Trial end date: 2007-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The randomized, double-blind, placebo-controlled study aim to evaluate the effect of 1-month therapy with folic acid (5 mg/day) on endothelial function and baroreceptor function in patients with heart failure.

Endothelial function will be studied non-invasively with flow-mediated dilation while for eveluating baroreceptor function sympathetic nervous system activity will be measured directly with microneurography in baseline condition and during infusion of sodium-nitroprusside.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Zurich
• Treatments: Folic Acid; Vitamin B Complex

Criteria

Inclusion Criteria:

• Heart failure (min. NYHA ll, LVEF <50%)

• Not smokers

• Written informed consent

Exclusion Criteria:

• Unstable heart failure

• Smoking

• Unstabile Angina Pectoris

• Endocrinologic disease such as Diabetes mellitus, Hypo- und Hyperthyroidism

• Alcohol abuse

• Epilepsia

• Treatment with folic acid antaponists Trimethoprim, Pyrimethamin, Methotrexat..

• Participation to one other clinical Study within 1 Month