Effect of GLP-1 Receptor Agonism After Sleeve Gastrectomy
Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
Participant gender:
Summary
Observational studies suggest that bariatric surgery is the most effective intervention for
weight loss. Comparative effectiveness of Roux-en-Y Gastric Bypass (RYGB) and Sleeve
Gastrectomy (SG) demonstrate that RYGB is significantly superior to SG in terms of weight
loss and glycemic control. Both RYGB and SG increase GLP-1 concentrations which directly
affect B-cell function. Data has shown that the postprandial rise in GLP-1 might affect
feeding behavior after RYGB and to a lesser extent SG, where the increase in GLP-1 is less
marked. In this study the investigators propose to randomize subjects undergoing SG to
receive either placebo or Liraglutide, a GLP-1 receptor agonist, to compare weight loss and
CV risk factors.