Effect of GLP-1 Receptor Agonists on Trabecular Bone Score and Visceral Adiposity in Postmenopausal Women With Type 2 Diabetes Mellitus.

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study will help determine the effect of Glucagon Like Peptide-1 (GLP-1)receptor agonists on bone strength in postmenopausal women with type 2 diabetes mellitus (T2DM)

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Mississippi Medical Center

Criteria

Inclusion Criteria:

• Diagnosis of Type 2 Diabetes Mellitus

• Postmenopausal female

• Age >55 years

• Hemoglobin A1c between 7-10% within 6 months of the first visit.

Exclusion Criteria:

• Patients with type 1 Diabetes mellitus

• Patients with a history of GLP-1 receptor agonist/DPP4 inhibitor use

• eGFR <30 ml/min in the last 3 months

• Patients with a history of pancreatitis

• Personal or family history of medullary thyroid cancer

• Patients with a history of treatment with anti-osteoporosis agents

• Documented secondary osteoporosis

• Documented presence of prosthesis or devices in the spine

• Unwilling or unable to consent