Effect of GTN and Diamox Measured by BOLD-Response.

• Status: Unknown status
• Trial end date: 2007-05-01
• Target enrollment: 0
• Participant gender: All

Summary

In healthy subjects different cerebral haemodynamic values wished to be determined after infusion of the NO donor Glyceryl trinitrate (GTN) and Diamox. The different values we wish to determine are:

• Blood-oxygenation-level-Dependent-signal (BOLD-signal) after visual stimulation.

• Changes in the diameter of a. cerebri media.

• Changes in the regional and global cerebral blodd flow (CBF) with the help of the arterial Spin labeling (ASL) method.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Danish Headache Center
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• healthy subjects

• age 18-55 years

• weight 50-100 kg

Exclusion Criteria:

• Tension type headache more the once per month.

• other types of headache

• Daily use of medication other the birthcontrol pills.

• Pregnant or lactating women.

• headache on the examination date.

• contraindications to MRI-scan.

• hypotension or hypertension.

• mental illness og substance abuse.

• other significant conditions determined by the examining doctor.