Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics
Status:
Completed
Trial end date:
2010-07-01
Target enrollment:
Participant gender:
Summary
This study evaluated the blood and blood cell concentrations of zidovudine and lamivudine in
men versus women and in those with versus without HIV infection. Additionally, markers of
side effects were correlated with blood levels of the drugs. The hypothesis was that women
and those with HIV would have higher drug levels, as well as markers of side effects.
Phase:
Phase 4
Details
Lead Sponsor:
University of Colorado, Denver
Collaborators:
National Institute of Allergy and Infectious Diseases (NIAID) University of Hawaii
Treatments:
Lamivudine Lamivudine, zidovudine drug combination Zidovudine