Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

• Status: Unknown status
• Trial end date: 2009-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.

The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bispebjerg Hospital
• Collaborators: Lund University; Ministry of the Interior and Health, Denmark; The Danish Rheumatism Association
• Treatments: Ibuprofen

Criteria

Inclusion Criteria:

• Age 50 to 70 years

• Bilateral tibiofemoral osteoarthritis of the knee on x-ray

• American College of Rheumatology (ACR) clinical classification criteria

Exclusion Criteria:

• Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases

• Excess alcohol use (> 21 alcoholic drinks per week)

• Severe overweight (BMI > 35)

• History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion