Effect of Glycopyrronium in Combination With Tropisetron in Anti-postoperative Nausea and Vomiting

• Status: Recruiting
• Trial end date: 2022-09-15
• Target enrollment: 0
• Participant gender: All

Summary

To compare the anti-nausea and vomiting effect between glycopyrronium in combination with tropisetron and normal saline in combination with tropisetron for patients receiving elective surgery under general anesthesia. Based on this study the investigators intend to explore the feasibility of using glycopyrronium as adjuvant drug to prevent postoperative nausea and vomiting.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University
• Collaborators: Chongqing General Hospital; Chongqing Jiangbei Hospital of Traditional Chinese Medicine; Chongqing Liangping District People's Hospital; Chongqing Medical University; Chongqing Traditional Chinese Medicine Hospital; Chongqing University Three Gorges Hospital; Department of Anesthesiology, Daping Hospital, Institute of Surgery Research, the Army Medical University; First Affiliated Hospital of Chongqing Medical University; Fuling Hospital affiliated to Chongqing University; People's Hospital of Changshou Chongqing; People's Hospital of Chongqing Hechuan; People's Hospital of Shapingba District， Chongqing; People's Hospital of Xiushan County; Qianjiang Central Hospital of Chongqing; Stomatological Hospital of Chongqing Medical University; The First People's Hospital Of Chongqing Liang Jiang New Area; The Ninth People's Hospital of Chongqing; The People's Hospital of Chongqing Kaizhou District; The People's Hospital of DAZU ，Chongqing; The People's Hospital of Nanchuan; Wushan County People's Hospital
• Treatments: Glycopyrrolate; Tropisetron

Criteria

Inclusion Criteria:

• Non-cardiac surgery

• American Society of Anesthesiologists classification I-III

• Receive general anesthesia

• Voluntarily receive postoperative intravenous controlled analgesia

Exclusion Criteria:

• Puerpera or lactation women

• Allergy or existing contraindication to glycopyrronium and tropisetron

• Participate in other clinical drug trials within three months

• Can not follow with the study procedure