Effect of Head Position on MACEI of Sevoflurane in Children With Obstructive Airway

• Status: Unknown status
• Trial end date: 2018-10-31
• Target enrollment: 0
• Participant gender: All

Summary

Children scheduled for tonsillectomy surgery were recruited into the study. General anesthesia was induced with 8% sevoflurane inhaled with 8 l.min-1 of oxygen via mask, followed by adjustment of inspired sevoflurane to the target concentration based on the result in previous patient at which laryngoscopy and tracheal intubation were attempted and maintained for 12 min. All responses to tracheal intubation were assessed. At the end of the procedure, sevoflurane was titrated to the target concentration, which was kept constant for 12 min before a standard stimulus was applied to determine whether the children was awake. The Dixon's 'up and down'method was used to determine progression of subsequent concentrations.The aim of this study was to determine whether the minimum alveolar concentration of endotracheal intubation（MACEI）of sevoflurane in children with obstructive airway are different from that observed in normal children.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
• Treatments: Sevoflurane

Criteria

Inclusion Criteria:

• class I or II

• children aged 2-8 years

• children with obstruction airway under general anesthesia undergoing tonsillectomy surgery

• signed informed consent

Exclusion Criteria:

• Patients with a history of adverse reactions to sevoflurane

• Patients with a potentially difficult airway (Mallampati III or IV, a limited mouth opening and/or cervical spine disease)

• Patients with reactive airway disease

• Signs of upper respiratory infection

• Violate experimental scheme

• refused to participate