Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218

• Status: Not yet recruiting
• Trial end date: 2024-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate single-dose PK of VIR-2218 following a SC injection of VIR-2218 administered at a dose up to 200 mg in participants with liver cirrhosis with various degrees of impaired hepatic function compared with healthy participants with normal hepatic function.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Vir Biotechnology, Inc.

Criteria

Inclusion Criteria:

• Must be ≥18 to ≤70 years of age at screening

• Must have a calculated BMI from 18.5 ≤ BMI ≤ 40 kg/m2

• All participants must have an eGFR ≥ 60 mL/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation

Inclusion criteria: Healthy matched participants

• Must in the opinion of the Investigator, be in good health based upon medical history, vital signs, physical examination, and screening laboratory evaluations

Inclusion criteria: Hepatic impaired participants

• Apart from hepatic insufficiency, participants must, in the opinion of the Investigator be sufficiently healthy for study participation based on medical history, physical examination, vital signs, and screening laboratory evaluations

• Participant is considered to have chronic, stable moderate, severe, mild HI (of any etiology excluding chronic HBV and HDV) and has been clinically stable per Investigator assessment for at least 1 month prior to screening

• CPT score of 5 to 6 for mild HI at screening and on Day 1 of study

• CPT score 7-9 for moderate HI at screening and on Day 1 of study

• CPT score 10-15 severe HI at screening and on Day 1 of study

Exclusion Criteria:

• Participants with unstable cardiac function or evidence of previous myocardial infarction in the past 12 months or any clinically significant active cardiovascular disease that, in the opinion of the Investigator, could interfere with the safety of the participant

• Any clinically significant conduction abnormality or arrhythmia (including non-sustained or sustained ventricular tachycardia as per Investigator's assessment)

• Infection with human immunodeficiency virus (HIV), hepatitis A virus (HAV), HBV (positive HBsAg or positive hepatitis B core antibody with negative hepatitis B surface antibody), hepatitis C virus (HCV), HDV or hepatitis E virus (HEV). HCV antibody positive participants with a negative HCV RNA are eligible. HDV antibody positive participants with a negative HDV RNA are eligible

Exclusion criteria: Healthy matched participants

• Systolic BP is outside the range of 90-160 mmHg, or diastolic BP is outside the range of 45-95 mmHg or heart rate is outside the range of 50-100 beats per minute (bpm) for female participants or 45-100 bpm for male participants at screening

• Use of any prescription medications or over-the-counter medications within 30 days prior to D1 of study participation

Exclusion criteria: Participants with Hepatic impairment

• Not on stable dose and regimen of any medication

• Acute or worsening chronic hepatitis

• Participants requiring paracentesis more than once a month

• Participants with refractory encephalopathy or significant Central Nervous System

• History of gastric or esophageal variceal bleeding within the past 6 months

• Participants with Transjugular Intrahepatic Portosystemic Shunt (TIPS) placement

• Presence of hepatopulmonary or hepatorenal syndrome

• Presence of primarily cholestatic liver diseases

• History of or currently listed for liver transplantation