Effect of High vs. Low MAP Levels on Clinical Outcomes in Elderly Patients During Noncardiothoracic Surgery

• Status: Unknown status
• Trial end date: 2017-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This will be a multicentre, randomised, controlled and prospective clinical trial. All participants provided their written informed consent to participate in a randomized trial that examined the effects of low-level MAP (60-70 mmHg) vs. high-level MAP (90-100 mmHg) in elderly patients (65 or more years of age) during noncardiothoracic surgery under general anesthesia. The investigators hypothesise high-level blood presure of the intervention for reducing the incidence of post-operative complications.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hu Anmin
• Collaborators: Henan Provincial Hospital; Henan Provincial People's Hospital; Sichuan Provincial People's Hospital; Taihe Hospital; The Affiliated Hospital Of Guizhou Medical University; The Third Affiliated Hospital of Kunming Medical College.; West China Hospital
• Treatments: Anesthetics; Oxymetazoline; Phenylephrine; Urapidil

Criteria

Inclusion Criteria:

• male and females, American Society of Anesthesiologists I-II-III, 65 or more years of age, scheduled to undergo noncardiothoracic surgery with general anesthesia are enrolled.

Exclusion Criteria:

• the patient suffered from Cardiovascular Disease and Metabolic Diseases, such as hypertension, cardiac disease, diabetes;

• the patient has severe liver, kidney or blood disease;

• the patient is accompanied severe cognitive impairment (Mini-Mental State Examination (MMSE) score < 15);

• preoperative history of schizophrenia, epilepsy, parkinsonism, use of cholinesterase inhibitor, or levodopa treatment;

• use of haloperidol or other neuroleptics during or after anesthesia;

• neurosurgery;

• individuals unlikely to survive for >24 hrs; previous participation in this study.