Effect of House Dust Mite Allergen Challenge in Persons Using 1200 mg Gamma Tocopherol Supplements
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Twenty, house dust mite (HDM)-allergic non-smoking subjects with or without mild asthma
between the ages 18-50 will be recruited. The primary endpoint will be nasal eosinophilia.
Each volunteer will be screened with skin testing, pulmonary function testing and induced
sputum. If eligible they will return for baseline nasal allergen challenge and lavage.
Approximately two weeks later they will return for gamma tocopherol (gT) dosing visit. After
completing 14 days of daily high dose (1200mg) gT, they will return for a second nasal
allergen challenge. This visit will also include pulmonary function testing and blood draw.
The purpose of this study is to determine if high dose gamma tocopherol therapy can reduce
allergen induced nasal inflammation.
Phase:
Phase 1
Details
Lead Sponsor:
University of North Carolina, Chapel Hill
Treatments:
alpha-Tocopherol gamma-Tocopherol Tocopherols Tocotrienols Vitamin E Vitamins