Effect of Human Plasma Protein Transfusion With and Without Crystalloids During Major Liver Resection Surgeries

• Status: Recruiting
• Trial end date: 2021-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Evaluation of acid-base and electrolyte changes after administration of commonly used colloid solutions (plasma protein fraction contains 5% albumin), and crystalloids (saline 0.9% and lactated ringers solutions) is the primary endpoint of this study. The secondary endpoints are to study dilution acidosis and changes in plasma volume induced by albumin versus crystalloids and their effect on tissue perfusion by randomizing patients into two groups where each group receives intraoperatively one type of the two fluids. Changes in acid-base, electrolytes, and dilution acidosis

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hamad Medical Corporation
• Treatments: Plasma protein fraction

Criteria

Inclusion Criteria:

• 18- 70 years old

• Not allergic to PPF5%, NS and RL,

• No morphological or functional cardiac valve/s changes, cardiac ischemia, significant arrhythmias or in failure,

• Patients with normal liver function tests before surgery and has no chronic active liver disease,

• Patients with normal kidney functions.

Exclusion Criteria:

• Patients with cardiac disease,

• Kidney disease,

• Liver dysfunction,

• Those who receive additional blood products other than PRBCs.