Effect of Hydroxyurea as Treatment for Primary Desmoid Tumors

• Status: Withdrawn
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the response rate of desmoid tumors to hydroxyurea. The investigators hypothesize that hydroxyurea will be a safe, non-toxic alternative to aggressive surgery or chemotherapy for this difficult to treat tumor.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Hospital of Philadelphia
• Treatments: Hydroxyurea

Criteria

Inclusion Criteria:

• Patients
• Histologically-confirmed diagnosis of desmoid tumor

• Measurable disease

• Stable hematologic, renal and hepatic parameters

• Negative pregnancy test for women of childbearing potential

Exclusion Criteria:

• Presence of a second neoplastic process

• Pregnant or breastfeeding women, fetuses, and prisoners will not be included in this study

• Patients receiving additional treatment for tumor other than pain control

• Patients having taken an investigational drug within the past 30 days