Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults

• Status: Recruiting
• Trial end date: 2022-10-12
• Target enrollment: 0
• Participant gender: All

Summary

The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Virginia
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Insulin; Insulin, Globin Zinc; Octreotide

Criteria

Inclusion Criteria:

• Healthy with no chronic illness

• Age 18-35

• Normal BMI (18-25)

• Normal screening labs or no clinically significant values

Exclusion Criteria:

• First degree relative with Type 2 Diabetes

• Smoking presently or in the past 6 months

• Medications that affect the vasculature

• Overweight or other indications of insulin resistance

• Elevated LDL cholesterol > 160

• Elevated BP > 140/90

• History of congestive heart failure, ischemic heart disease, severe pulmonary disease, liver or kidney disease, bleeding disorders

• Any vascular disease such as myocardial infarction, stroke, peripheral vascular disease

• Presence of an intracardiac or intrapulmonary shunt (we will screen for this by auscultation during the physical exam by PI).

• Pregnant or breastfeeding.

• Known hypersensitivity to perflutren (contained in Definity)