Effect of IV Infusion of Lidocaine Compared to IV Infusion of Dexmedetomidine on Proinflammatory Cytokines

• Status: Completed
• Trial end date: 2020-06-13
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed to compare between intravenous infusion of dexmedetomidine and intravenous infusion of lidocaine in reduction of proinflammatory cytokines as IL-6 and TNF-α, some stress reactions (serum insulin and serum lactate),and postoperative analgesic requirements in patients undergoing surgery for pelviabdominal cancers.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute, Egypt; Norma Osama Abdalla Zayed
• Collaborator: Abdelhamid, Bassant Mohamed, M.D.
• Treatments: Dexmedetomidine; Lidocaine

Criteria

Inclusion Criteria:

• American society of anesthesia (ASA) Physical Status classification:

ASA II physical status.

• Age between 18 to 60 years old.

• Patients who will undergo major pelviabdominal surgery.

Exclusion Criteria:

• Patient refusal.

• Allergy to local anesthetics.

• Cognitive disorders.

• uncontrolled diabetes or hypertension.