Overview

Effect of Inhaled Steroids on Gene Expression in the Lungs - 2

Status:
Terminated
Trial end date:
2014-12-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to assess the effect of inhaled beclomethasone (an inhaled corticosteroid) on the pattern of the lung airway epithelium and alveolar macrophages gene expression of healthy smokers. We hypothesize that the administration of beclomethasone will result in reversibility of some of the airway epithelium and alveolar macrophage gene expression changes induced by cigarette smoking.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Weill Medical College of Cornell University
Treatments:
Beclomethasone
Criteria
Inclusion Criteria:

All Smokers (Treated and Non-Treated)

- All study individual should be enrolled in Weill-IRB protocol #0005004439 entitled
"Evaluation of the Lungs of Normal (Smokers, Ex-smokers, Non-Smokers) Individuals with
Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy"

- All study subjects should be able to provide informed consent

- Current smokers with 15-to 40 pack-year history

- All study individuals should be healthy as per protocol #0005004439 entitled
"Evaluation of the Lungs of Normal (Smokers, Ex-smokers, Non-Smokers) Individuals with
Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy"

Non-Smokers

- All study individual should be enrolled in Weill-IRB protocol #0005004439 entitled
"Evaluation of the Lungs of Normal (Smokers, Ex-smokers, Non-Smokers) Individuals with
Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy"

- All study subjects should be able to provide informed consent

- All study individual should be healthy as per protocol #0005004439 entitled
"Evaluation of the Lungs of Normal (Smokers, Ex-smokers, Non-Smokers) Individuals with
Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy"

Exclusion Criteria:

All Smokers

- Smokers intending to quit smoking in the next 14 days.

- Individuals already receiving any lung related inhalers

- Females who are pregnant or nursing

Non-Smokers

Exclusion Criteria:

- Non-smokers who intend to start smoking in the next 14 days

- Individuals already receiving any lung related inhalers

- Females who are pregnant or nursing