Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation
Status:
Completed
Trial end date:
2000-03-01
Target enrollment:
Participant gender:
Summary
Previous studies have shown that insulin may stimulate the release of endothelin (ET) from
endothelial cells. This mechanism may contribute to the adverse vascular effects determined
by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local
hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess
the forearm blood flow response to ET receptor antagonism in control conditions and during
intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in
response to the different pharmacological stimuli.