Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Herbert Lindsley, MD
• Treatments: Lidocaine; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Age > 40 years

• Male or postmenopausal female

• Diagnosis of knee osteoarthritis

• DEXA bone density done within the past 12 months

• Painful knee, visual analogue scale (VAS) > 4 of (10=worst)

Exclusion Criteria:

• Diabetes Mellitus Type I or II

• Systemic inflammatory illness

• Systemic infections which may be aggravated by steroid therapy

• No current or previous (< 3 years) biphosphate therapy

• Previous knee replacement surgery

• No current or previous Parathyroid hormone (PTH) therapy