Effect of Intranasal Insulin on LH Concentrations in Man
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Over the last few years, studies have shown that men with type 2 diabetes sometimes develop a
condition called hypogonadotrophic hypogonadism (HH). People with this condition produce
little or no sex hormones. Obesity and metabolic syndrome are also associated with HH.
Research suggests that insulin in the brain may benefit the glands that release these
hormones. During this study, subjects will spray a small amount of insulin into their
nose.This will increase insulin concentrations in the brain. The purpose of this study is to
find out the effect of one dose of intranasal insulin on release of LH (a sex hormone) in
obese diabetic men with HH.