Effect of Intraoperative Sedation on PND in Elderly Patients

• Status: Not yet recruiting
• Trial end date: 2022-07-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to identify the effects of different depths of sedation and choices of sedative drugs on perioperative neurocognitive disorders in the elderly patients receiving hip surgery under spinal anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hebei Medical University Third Hospital
• Treatments: Anesthetics; Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

1. Acquisition of informed consent,

2. Patients with hip fracture surgery under spinal anesthesia,

3. Grade I to III based on American Society of Anesthesiologists ASA classification,

4. Age ≥65.

Exclusion Criteria:

1. There was a history of cardiovascular and cerebrovascular adverse events in the past six months, including myocardial infarction, angina pectoris, severe arrhythmia, stroke or transient ischemic attack (TIA)

2. Heart failure (NYHA III / IV and / or LVEF < 30%)

3. Bradycardia

4. Respiratory failure (need oxygen)

5. Glasgow Coma Scale ≤ 14 points

6. Severe hepatic and renal insufficiency (child Pugh grade B or C)

7. Preoperative cognitive impairment or sedative drugs (benzodiazepines, etc.).

8. Adverse reactions such as allergy to dexmedetomidine or / or propofol

9. Preoperative bilateral hip fracture or other trauma need simultaneous operation

10. Contraindications of spinal anesthesia