Effect of Intravenous Dynastat on Postoperative Sore Throat

• Status: Unknown status
• Trial end date: 2020-11-30
• Target enrollment: 0
• Participant gender: All

Summary

A postoperative sore throat (POST) after tracheal intubation is one of the most common postoperative problems causing dissatisfaction to participants, including sore throat, dry throat, cough, sputum, hoarseness and even dysphagia. Both nonpharmacological and pharmacological measures have been attempted to alleviate the incidence and severity of POST with variable success. Airway inflammation may be important in the pathogenesis of these symptoms in intubated participants but however, there was still no study to investigate the effect of cyclooxygenase-2 (COX-2) for the prevention of POST. So, the investigators' study will be the first one to investigate if perioperatively intravenous (IV) Dynastat injection can be used as a new indication for POST prevention.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Buddhist Tzu Chi General Hospital
• Treatments: Parecoxib

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists physical status 1 and 2

• Requiring general anesthesia with endotracheal intubation (ETGA) for elective non-cardiac surgery

• The anesthetic time after intubation will need 90 minutes at least.

Exclusion Criteria:

• Those with a preexisting cough, hoarseness or a sore throat

• Smoker

• History of asthma or chronic obstructive pulmonary disorder

• Vocal performer by occupation

• Recent or recurrent respiratory tract infection

• Risk factors for postoperative aspiration, for example obesity, pregnancy

• Allergic reaction to Dynastat, acetylsalicylic acid, sulfonamide or NSAIDs.

• Active GI bleeding or gastric ulcer

• Third trimester and during lactation

• Anticipated difficult intubation

• Mallampati grade >2

• Difficult mask ventilation requiring oral or nasal airway

• Cormack and Lehane grade III and IV on laryngoscopy

• Intubation attempt >1

• Moderate to severe liver dysfunction (Child-Pugh score >7)

• Severe renal dysfunction (Ccr < 30 ml/min)

• Congestive heart failure (NYHA II-IV)

• Those requiring orogastric or nasogastric tubes