Effect of Intravenous Lignocaine Infusion on Intraoperative End Tidal Desflurane Concentration Requirements

• Status: Completed
• Trial end date: 2021-11-19
• Target enrollment: 0
• Participant gender: All

Summary

Lignocaine is a local anaesthetic that is widely used in all medical and surgical fields. Many clinical studies have shown that intravenous (IV) lignocaine given in the perioperative period was safe, reduced airway complications, obtunds cough reflex, reduce sore throat, pain, opioid consumption, nausea, length of hospital stay. Multiple animal studies have shown that IV lignocaine was able to lower anaesthetic gas requirements. Desflurane is an anaesthetic gas that has a rapid onset and offset of action. This study aims to evaluate the effect of IV lignocaine infusion on desflurane requirements.

Hypothesis of the study is that IV lignocaine infusion reduces desflurane requirements.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universiti Kebangsaan Malaysia Medical Centre
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

1. American Society of Anaesthesiology (ASA) I or II patients.

2. Patients aged between 18-75 years of age.

3. Patients scheduled for elective laparoscopic cholecystectomy.

4. Patients scheduled for laparoscopic hernioplasty.

5. Patients scheduled for emergency laparoscopic appendicectomy.

6. Patients scheduled for emergency laparoscopic cystectomy.

7. Patient weight ranging from 50 - 100 kg.

8. Surgery lasting at least one hour.

Exclusion Criteria:

1. Patients with a known allergy to study drug.

2. Patients with body mass index (BMI) more than 35 kg m-2.

3. Patients who are taking sedatives.

4. Patients with chronic substance abuse.