Overview

Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients

Status:
Completed
Trial end date:
2021-08-30
Target enrollment:
0
Participant gender:
All
Summary
The main purpose of this study is to compare the myocardial protection effect of intravenous metoprolol combined with remote ischemic conditioning (RIC) and single treatment before reperfusion in Chinese patients with anterior STEMI. This study sought to find possible strategies to further improve myocardial protection in Chinese patients with anterior STEMI.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Harbin Medical University
Collaborator:
Beijing Chao Yang Hospital
Treatments:
Metoprolol
Criteria
Inclusion Criteria:

1. ages 18 to 80 years;

2. presenting within 12 h of symptoms onset, with anterior STEMI and planned for pPCI;
anterior STEMI was defined as the occurrence of >20 min of chest pain and ST-segment
elevation (>2 mm) in at least 2 contiguous precordial leads;

3. sign informed consent;

Exclusion Criteria:

1. systolic blood pressure < 110mmHg;

2. cardiogenic shock or with heart failure symptoms, Killip III~IV;

3. allergic history of metoprolol;

4. history of asthma or the need for bronchodilators;

5. PR interval > 240ms, II~III atrioventricular blockļ¼›

6. heart rate < 60 beats/min;

7. unable to consent;

8. pregnancy and lactation women;

9. life expectancy for diseases (i.e. cancer) < 1 year.