Effect of Ivabradine and Beta-blockers Combination Versus Beta-blockers Up-titration on Right Ventricular Pacing
Status:
Withdrawn
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
The aim of this prospective, randomized and controlled trial is to evaluate the use of the
ivabradine in combination to a low-dose of beta-blocker (bisoprolol) versus up-titration of
beta-blocker (bisoprolol) to obtain heart rate (HR) control with reduction in RV pacing in
single-chamber or dual chambers ICD recipients HF patients with moderate to severe left
ventricular dysfunction (FE ≤ 40%) and an heart rate ≥ 70 bpm in sinus rhythm over a
12-months follow up.
Besides the investigators want to assess if the combination of ivabradine to a low-dose of
beta-blocker (bisoprolol) versus up-titration of beta-blocker (bisoprolol) may determine a
lower degree of left ventricular dysfunction progression, the reduction of ventricular
arrhythmias burden and ICD appropriate therapy occurrence and the improvement of quality of
life in ICD heart failure patients.