Effect of Ketorolac on Post Adenotonsillectomy Pain

• Status: Recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This randomized prospective study aims to determine the effect of ketorolac on the total dose of morphine required to achieve postoperative analgesia in children with obstructive sleep apnea (OSA) undergoing adenotonsillectomy. Participants will be randomly assigned to a study group where they will receive ketorolac in addition to the standard of care treatment or will receive only the standard of care pain management. The researchers hypothesize that by administering ketorolac at the end of the procedure once hemostasis has been achieved, it will be possible to decrease the amount of morphine administered in the post-anesthesia care unit (PACU). This study aims to provide a more comprehensive understanding of the efficacy and safety of the current standard post-operative analgesic regimen employed at the study institution, in which opioid analgesia currently plays a prominent role.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Emory University
• Treatments: Ketorolac; Ketorolac Tromethamine; Morphine

Criteria

Inclusion Criteria:

• Diagnosis of sleep disordered breathing or obstructive sleep apnea

• Children undergoing elective tonsillectomy or adenotonsillectomy at Children's Healthcare of Atlanta Egleston location

• Parent or legal guardian willing to participate, and able to understand and sign the provided informed consent

Exclusion Criteria:

• Known coagulation defect

• Patients on longstanding NSAID therapy

• Known renal impairment

• Patients may also be excluded at the discretion of the investigator