Effect of LOW-molecular-weight Heparin in Reducing Radial Artery Occlusion Rate After Transradial Coronary Catheterization
Status:
Completed
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
The purpose of the LOW-RAO study is to determine the most effective treatment for radial
artery occlusion (RAO) after transradial coronary catheterization (both angiography and PCI).
This is a prospective, single-center, randomized controlled, open-label study that will
randomize patients with RAO into two groups, one receiving anticoagulation with
low-molecular-weight-heparin (LMWH) and the other receiving no anticoagulation. RAO will be
detected by radial artery ultrasound up to 24 hours after the procedure.
Study objectives:
1. Primary objective:
a. To evaluate the effect of treatment with LMWH, in patients (both symptomatic and
asymptomatic) with RAO after a coronary catheterization procedure (both angiography and
percutaneous coronary intervention-PCI), in improving patency rates of the radial artery
at 1 month after the procedure, compared with no-LMWH treatment.
2. Secondary objectives:
1. To compare RAO as defined by different methods (pulse palpation, modified Allen's
test, reverse Barbeau test, radial artery ultrasound).
2. To compare local access site and systemic complications (bleeding events,
pseudoaneurysm, arteriovenous fistula) at 1 month after the procedure in the LMWH
and no-LMWH groups.
3. To evaluate RAO incidence in coronary angiography and PCI groups.
4. To determine risk factors for RAO in coronary catheterization procedures.