Effect of Lactobacillus Plantarum 299v on Symptoms of Irritable Bowel Syndrome

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

In patients with IBS, will supplementation with a probiotic demonstrate symptomatic efficacy and will the probiotic influence gut microflora and thus improve clinical outcomes, as compared to no intervention.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Stellenbosch
• Collaborators: National Research Foundation (NRF) (RSA); Nestlè Nutrition Institute Africa
• Treatments: Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• fulfillment of the Rome II criteria for IBS,

• availability of at least one colonoscopy within the last three years,

• aged 18 or older at the time of screening,

• provision of written informed consent,

• commitment of availability throughout the 12 week study period.

Exclusion Criteria:

• major abdominal surgery in the past other than other than appendectomy, caesarean section, tubal laparoscopic cholecystectomy, abdominal wall hernia repair or/and hysterectomy,

• current use of antibiotics,

• history of organic intestinal disease,

• pregnant or breastfeeding mothers,

• chronic infectious disease like HIV or tuberculosis, and

• unable to understand English or Afrikaans.