Effect of Lactulose and/or Polyethylene Glycol Solution for Bowel Preparation for Colonscopy Procedures
Status:
Recruiting
Trial end date:
2022-08-31
Target enrollment:
Participant gender:
Summary
Colonoscopy is the most useful exam used to evaluate colorectal diseases, like colorectal
polyps and cancer. The appropriate bowel preparation is indispensable for colonoscopy
procedures. Polyethylene glycol solution (PEG) is the most frequent laxative medication.
However, the taste is poor, and patients need to drink a lot of liquids to obtain adequate
visualization of the mucosal surface. In fact, no laxative has all the characteristics of an
ideal medication. Lactulose is an osmotic laxative which widely used in cirrhosis and
constipation patients, and could inhibit bacterial in the colon to increase colon cleanliness
and prolong the effect time of PEG. Previous study demonstrate PEG combined with lactulose
has a significant improvement in the quality of bowel preparation compared with PEG alone.
The present study aim to assess the efficacy of lactulose with or without PEG in bowel
preparation to improve mucosal visualization, reduced volume of fluid consumed, and
preparation intolerance.
Phase:
Phase 3
Details
Lead Sponsor:
Sichuan University
Collaborators:
Affiliated Hospital of North Sichuan Medical College Affiliated Hospital of Southwest Medical University