Effect of Licorice and Hydrochlorothiazide on Plasma Potassium
Status:
Completed
Trial end date:
2009-01-01
Target enrollment:
Participant gender:
Summary
This clinical trial is designed to study the effect of the combination of licorice and
hydrochlorothiazide on plasma potassium levels in volunteers. In one arm, 10 healthy
volunteers will be given 32 grams of licorice a day together with a 25 mg dose of daily
hydrochlorothiazide for 14 days. This combination is compared with 32 grams of licorice a day
for 14 days given in the other arm. The study is a randomized, open-label cross-over trial.
There is at least a 3-week wash-out between the arms. The hypothesis is that the combination
of licorice and hydrochlorothiazide will cause hypokalemia. The main outcome measure is the
change in the plasma level of potassium between the arms.